Copied!

Pathway Search


Pyrimidine metabolism

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
UMP + H2O <=> uridine + phosphate 3.1.3.1 alkaline phosphatase
3.1.3.2 acid phosphatase
3.1.3.25 inositol-phosphate phosphatase
3.1.3.31 nucleotidase
3.1.3.5 5'-nucleotidase
3.1.3.89 5'-deoxynucleotidase
3.1.3.91 7-methylguanosine nucleotidase
3.1.4.16 2',3'-cyclic-nucleotide 2'-phosphodiesterase
3.6.1.9 nucleotide diphosphatase
–
–
–
–
–
–
–
–
–
2''-deoxyuridine + phosphate <=> 2-deoxy-alpha-D-ribose_1-phosphate + Uracil 2.4.2.1 purine-nucleoside phosphorylase
2.4.2.2 pyrimidine-nucleoside phosphorylase
2.4.2.3 uridine phosphorylase
2.4.2.4 thymidine phosphorylase
–
–
–
–
Uracil + acceptor + H2O <=> Barbiturate + reduced_acceptor + H+ 1.17.99.4 uracil/thymine dehydrogenase
–
dUTP + H2O <=> H+ + dUMP + diphosphate 3.6.1
3.6.1.23 dUTP diphosphatase
3.6.1.8 ATP diphosphatase
3.6.1.9 nucleotide diphosphatase
–
–
–
–
ATP + CMP <=> ADP + CDP 2.7.1.48 uridine/cytidine kinase
2.7.4.14 UMP/CMP kinase
2.7.4.25 (d)CMP kinase
2.7.4.3 adenylate kinase
2.7.4.4 nucleoside-phosphate kinase
2.7.4.8 guanylate kinase
–
–
–
–
–
–
ATP + UTP + NH3 <=> ADP + phosphate + CTP + H+ 6.3.4.2 CTP synthase (glutamine hydrolysing)
–
ITP + cytidine <=> IDP + CMP 2.7.1.48 uridine/cytidine kinase
2.7.1.B20
–
–
phosphate + uridine <=> alpha-D-ribose_1-phosphate + Uracil 2.4.2.2 pyrimidine-nucleoside phosphorylase
2.4.2.3 uridine phosphorylase
2.4.2.4 thymidine phosphorylase
–
–
–
H+ + H2O + dCTP <=> NH3 + dUTP 3.5.4.13 dCTP deaminase
–
formate + UTP + H+ <=> dUTP + CO2 + H2O 1.1.98.6 ribonucleoside-triphosphate reductase (formate)
–
H+ + H2O + 2''-deoxycytidine <=> 2''-deoxyuridine + NH3 3.5.4.12 dCMP deaminase
3.5.4.5 cytidine deaminase
–
–
uridine_2''3''-cyclic_monophosphate + H2O <=> uridine_3''-monophosphate + H+ 3.1.4.16 2',3'-cyclic-nucleotide 2'-phosphodiesterase
4.6.1.18 pancreatic ribonuclease
–
–
orotidine_5''-phosphate + diphosphate <=> 5-phospho-alpha-D-ribose_1-diphosphate + Orotate 2.4.2.10 orotate phosphoribosyltransferase
–
UTP + H2O <=> UMP + diphosphate + H+ 3.1.3.31 nucleotidase
3.1.4.1 phosphodiesterase I
3.6.1.23 dUTP diphosphatase
3.6.1.65 (d)CTP diphosphatase
3.6.1.8 ATP diphosphatase
3.6.1.9 nucleotide diphosphatase
–
–
–
–
–
–
dCTP + cytidine <=> dCDP + CMP 2.7.1.48 uridine/cytidine kinase
–
thymidine + acceptor <=> 2'-deoxynucleoside + thymine 2.4.2.6 nucleoside deoxyribosyltransferase
–
uridine_3''-monophosphate + H2O <=> uridine + phosphate 3.1.3.1 alkaline phosphatase
3.1.3.2 acid phosphatase
3.1.3.25 inositol-phosphate phosphatase
3.1.3.31 nucleotidase
3.1.3.6 3'-nucleotidase
3.1.30.1 Aspergillus nuclease S1
3.1.4.16 2',3'-cyclic-nucleotide 2'-phosphodiesterase
–
–
–
–
–
–
–
dCDP + thioredoxin_disulfide + H2O <=> CDP + thioredoxin 1.17.4.1 ribonucleoside-diphosphate reductase
1.17.4.2 ribonucleoside-triphosphate reductase (thioredoxin)
–
–
cytidine + phosphate <=> cytosine + alpha-D-ribose_1-phosphate 2.4.2.2 pyrimidine-nucleoside phosphorylase
2.4.2.3 uridine phosphorylase
–
–
L-aspartate + Carbamoyl_phosphate <=> H+ + L-carbamoyl-L-aspartate + phosphate 2.1.3.2 aspartate carbamoyltransferase
–
UTP + uridine <=> UDP + UMP 2.7.1.48 uridine/cytidine kinase
–
2''-deoxycytidine + ATP <=> dCMP + ADP + H+ 2.7.1.113 deoxyguanosine kinase
2.7.1.145 deoxynucleoside kinase
2.7.1.20 adenosine kinase
2.7.1.21 thymidine kinase
2.7.1.213 cytidine kinase
2.7.1.74 deoxycytidine kinase
2.7.1.76 2'-deoxyadenosine kinase
–
–
–
–
–
–
–
diphosphate + UMP <=> 5-phospho-alpha-D-ribose_1-diphosphate + Uracil 2.4.2.10 orotate phosphoribosyltransferase
2.4.2.9 uracil phosphoribosyltransferase
–
–
5,6-dihydrouracil + NAD+ <=> Uracil + NADH + H+ 1.3.1.1 dihydropyrimidine dehydrogenase (NAD+)
1.3.1.2 dihydropyrimidine dehydrogenase (NADP+)
–
–
dTDP + ATP <=> dTTP + ADP 2.7.4.6 nucleoside-diphosphate kinase
–
formate + CTP + H+ <=> dCTP + CO2 + H2O 1.1.98.6 ribonucleoside-triphosphate reductase (formate)
–
dUMP + 5,10-methylenetetrahydrofolate + NADPH + H+ <=> dTMP + tetrahydrofolate + NADP+ 1.5.1.3 dihydrofolate reductase
2.1.1.148 thymidylate synthase (FAD)
–
–
dUTP + H2O <=> dUDP + phosphate + H+ 3.6.1.15 nucleoside-triphosphate phosphatase
3.6.1.39 thymidine-triphosphatase
3.6.4.12 DNA helicase
–
–
–
P1,P4-bis(5''-uridyl)_tetraphosphate + H2O <=> UTP + UMP 3.1.4.1 phosphodiesterase I
3.6.1.17 bis(5'-nucleosyl)-tetraphosphatase (asymmetrical)
–
–
dCTP + H2O <=> dUMP + diphosphate + NH3 3.5.4.30 dCTP deaminase (dUMP-forming)
–
(R)-5,6-Dihydrothymine + NAD+ <=> thymine + NADH + H+ 1.3.1.1 dihydropyrimidine dehydrogenase (NAD+)
–
dCTP + thioredoxin_disulfide + H2O <=> CTP + thioredoxin 1.17.4.1 ribonucleoside-diphosphate reductase
1.17.4.2 ribonucleoside-triphosphate reductase (thioredoxin)
–
–
L-dihydroorotate + fumarate <=> Orotate + succinate 1.3.98.1 dihydroorotate dehydrogenase (fumarate)
–
L-dihydroorotate + a_quinone <=> Orotate + a_quinol 1.3.5.2 dihydroorotate dehydrogenase (quinone)
–
5,10-methylenetetrahydrofolate + dUMP <=> dTMP + 7,8-dihydrofolate 2.1.1.45 thymidylate synthase
–
dUTP + cytidine <=> dUDP + CMP 2.7.1.48 uridine/cytidine kinase
–
CDP + H2O <=> phosphate + CMP + H+ 3.1.3.2 acid phosphatase
3.1.3.31 nucleotidase
3.1.4.16 2',3'-cyclic-nucleotide 2'-phosphodiesterase
3.1.4.37 2',3'-cyclic-nucleotide 3'-phosphodiesterase
3.6.1.15 nucleoside-triphosphate phosphatase
3.6.1.5 apyrase
3.6.1.6 nucleoside diphosphate phosphatase
3.6.1.9 nucleotide diphosphatase
–
–
–
–
–
–
–
–
dCDP + H2O <=> dCMP + phosphate + H+ 3.6.1.12 dCTP diphosphatase
3.6.1.15 nucleoside-triphosphate phosphatase
3.6.1.55 8-oxo-dGTP diphosphatase
3.6.1.6 nucleoside diphosphate phosphatase
3.6.1.9 nucleotide diphosphatase
–
–
–
–
–
UDP-glucose + H2O <=> UMP + alpha-D-aldose_1-phosphate + H+ 3.1.4.1 phosphodiesterase I
3.6.1.45 UDP-sugar diphosphatase
3.6.1.8 ATP diphosphatase
3.6.1.9 nucleotide diphosphatase
–
–
–
–
dUDP + ATP <=> dUTP + ADP 2.7.4.6 nucleoside-diphosphate kinase
–
pseudouridine + ATP <=> H+ + pseudouridine_5''-phosphate + ADP 2.7.1.83 pseudouridine kinase
–
D-ribose_5-phosphate + Uracil <=> H2O + pseudouridine_5''-phosphate 4.2.1.70 pseudouridylate synthase
–
dUTP + thioredoxin_disulfide + H2O <=> UTP + thioredoxin 1.17.4.2 ribonucleoside-triphosphate reductase (thioredoxin)
–
H+ + H2O + cytidine <=> uridine + NH3 3.5.4.5 cytidine deaminase
–
cytidine-3''-monophosphate + H2O <=> cytidine + phosphate 3.1.3.1 alkaline phosphatase
3.1.3.2 acid phosphatase
3.1.3.25 inositol-phosphate phosphatase
3.1.3.31 nucleotidase
3.1.3.6 3'-nucleotidase
3.1.4.16 2',3'-cyclic-nucleotide 2'-phosphodiesterase
–
–
–
–
–
–
thiamine_diphosphate + H2O <=> H+ + thiamine_phosphate + phosphate 3.1.3.1 alkaline phosphatase
3.1.3.100 thiamine phosphate phosphatase
3.1.3.2 acid phosphatase
3.6.1
3.6.1.15 nucleoside-triphosphate phosphatase
3.6.1.28 thiamine-triphosphatase
3.6.1.5 apyrase
3.6.1.55 8-oxo-dGTP diphosphatase
3.6.1.6 nucleoside diphosphate phosphatase
–
–
–
–
–
–
–
–
–
dTTP + H2O <=> dTDP + phosphate + H+ 3.1.3.2 acid phosphatase
3.6.1.15 nucleoside-triphosphate phosphatase
3.6.1.39 thymidine-triphosphatase
3.6.1.5 apyrase
3.6.1.9 nucleotide diphosphatase
3.6.4.12 DNA helicase
–
–
–
–
–
–
dCTP + uridine <=> dCDP + UMP 2.7.1.48 uridine/cytidine kinase
–
Uracil + FMNH2 + O2 <=> (Z)-3-ureidoacrylate_peracid + FMN 1.14.99.46 pyrimidine oxygenase
–
CDP + ATP <=> CTP + ADP 2.7.4.3 adenylate kinase
2.7.4.6 nucleoside-diphosphate kinase
–
–
dCTP + H2O <=> H+ + dCMP + diphosphate 3.6.1.12 dCTP diphosphatase
3.6.1.23 dUTP diphosphatase
3.6.1.55 8-oxo-dGTP diphosphatase
3.6.1.65 (d)CTP diphosphatase
3.6.1.8 ATP diphosphatase
3.6.1.9 nucleotide diphosphatase
–
–
–
–
–
–
dCMP + H2O + 5,10-methylenetetrahydrofolate <=> 2''-deoxy-5-hydroxymethylcytidine_5''-phosphate + tetrahydrofolate 2.1.2.8 deoxycytidylate 5-hydroxymethyltransferase
2.1.2.B2
–
–
H2O + CTP <=> H+ + phosphate + CDP 3.1.3.2 acid phosphatase
3.1.3.31 nucleotidase
3.1.3.5 5'-nucleotidase
3.1.3.8 3-phytase
3.1.4.16 2',3'-cyclic-nucleotide 2'-phosphodiesterase
3.1.4.37 2',3'-cyclic-nucleotide 3'-phosphodiesterase
3.6.1.15 nucleoside-triphosphate phosphatase
3.6.1.28 thiamine-triphosphatase
3.6.1.3 adenosinetriphosphatase
3.6.1.5 apyrase
3.6.1.6 nucleoside diphosphate phosphatase
3.6.1.9 nucleotide diphosphatase
3.6.1.B17
3.6.4.12 DNA helicase
3.6.4.13 RNA helicase
3.6.4.B10
3.6.4.B6
5.6.1.5 proteasome ATPase
7.1.2.2 H+-transporting two-sector ATPase
7.6.2.2 ABC-type xenobiotic transporter
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
3-hydroxypropionate + NADP+ <=> malonate_semialdehyde + NADPH + H+ 1.1.1
1.1.1.2 alcohol dehydrogenase (NADP+)
1.1.1.276 serine 3-dehydrogenase (NADP+)
1.1.1.298 3-hydroxypropionate dehydrogenase (NADP+)
–
–
–
–
dATP + cytidine <=> dADP + CMP 2.7.1.48 uridine/cytidine kinase
–
5,6-dihydrouracil + NADP+ <=> Uracil + NADPH + H+ 1.3.1.1 dihydropyrimidine dehydrogenase (NAD+)
1.3.1.2 dihydropyrimidine dehydrogenase (NADP+)
–
–
3-Oxo-3-ureidoisobutyrate + H2O <=> methylmalonate + Urea 3.5.1.95 N-malonylurea hydrolase
–
phosphate + thymidine <=> 2-deoxy-alpha-D-ribose_1-phosphate + thymine 2.4.2.2 pyrimidine-nucleoside phosphorylase
2.4.2.3 uridine phosphorylase
2.4.2.4 thymidine phosphorylase
–
–
–
ATP + L-glutamine + HCO3- + H2O <=> L-glutamate + Carbamoyl_phosphate + ADP + phosphate + H+ 6.3.4.16 carbamoyl-phosphate synthase (ammonia)
6.3.5.5 carbamoyl-phosphate synthase (glutamine-hydrolysing)
–
–
dCMP + H2O <=> 2''-deoxycytidine + phosphate 3.1.3.1 alkaline phosphatase
3.1.3.2 acid phosphatase
3.1.3.31 nucleotidase
3.1.3.5 5'-nucleotidase
3.1.3.89 5'-deoxynucleotidase
–
–
–
–
–
H+ + 2-aminoacrylate + H2O <=> malonate_semialdehyde + NH3 3.5.1
–
L-dihydroorotate + NAD+ <=> H+ + Orotate + NADH 1.3.1.14 dihydroorotate dehydrogenase (NAD+)
–
CMP + H2O <=> cytidine + phosphate 3.1.3.1 alkaline phosphatase
3.1.3.2 acid phosphatase
3.1.3.25 inositol-phosphate phosphatase
3.1.3.31 nucleotidase
3.1.3.5 5'-nucleotidase
3.1.3.91 7-methylguanosine nucleotidase
–
–
–
–
–
–
dATP + uridine <=> dADP + UMP 2.7.1.48 uridine/cytidine kinase
–
cytidine + ATP <=> CMP + ADP + H+ 2.7.1.145 deoxynucleoside kinase
2.7.1.213 cytidine kinase
2.7.1.48 uridine/cytidine kinase
2.7.1.74 deoxycytidine kinase
2.7.1.76 2'-deoxyadenosine kinase
2.7.1.B20
–
–
–
–
–
–
UTP + cytidine <=> UDP + cytidine_5''-phosphate 2.7.1.213 cytidine kinase
2.7.1.48 uridine/cytidine kinase
2.7.1.74 deoxycytidine kinase
–
–
–
ATP + dCMP <=> ADP + dCDP 2.7.4.13 (deoxy)nucleoside-phosphate kinase
2.7.4.14 UMP/CMP kinase
2.7.4.25 (d)CMP kinase
2.7.4.3 adenylate kinase
2.7.4.9 dTMP kinase
–
–
–
–
–
(R)-5,6-Dihydrothymine + H2O <=> N-carbamoyl-beta-aminoisobutyric_acid 3.5.2.2 dihydropyrimidinase
–
dCDP + ATP <=> dCTP + ADP 2.7.4.6 nucleoside-diphosphate kinase
–
CMP + H2O <=> cytosine + D-ribose_5-phosphate 3.2.2.10 pyrimidine-5'-nucleotide nucleosidase
–
dTTP + uridine <=> dTDP + UMP 2.7.1.48 uridine/cytidine kinase
–
ATP + UTP + L-glutamine + H2O <=> H+ + ADP + phosphate + CTP + L-glutamate 6.3.4.2 CTP synthase (glutamine hydrolysing)
–
ATP + UMP <=> ADP + UDP 2.7.4.14 UMP/CMP kinase
2.7.4.22 UMP kinase
2.7.4.4 nucleoside-phosphate kinase
2.7.4.8 guanylate kinase
–
–
–
–
CTP + H2O <=> H+ + CMP + diphosphate 3.6.1.65 (d)CTP diphosphatase
3.6.1.8 ATP diphosphatase
3.6.1.9 nucleotide diphosphatase
–
–
–
uridine + H2O <=> D-ribose + Uracil 3.2.2.1 purine nucleosidase
3.2.2.3 uridine nucleosidase
3.2.2.7 adenosine nucleosidase
3.2.2.8 ribosylpyrimidine nucleosidase
–
–
–
–
5-Methylcytosine + H2O + H+ <=> thymine + NH3 3.5.4.1 cytosine deaminase
3.5.4.21 creatinine deaminase
–
–
N-Carbamoyl-beta-alanine + H2O + H+ <=> beta-Alanine + NH3 + CO2 3.5.1.6 beta-ureidopropionase
–
uridine + GTP <=> H+ + UMP + GDP 2.7.1.48 uridine/cytidine kinase
–
cytidine + GTP <=> H+ + CMP + GDP 2.7.1.213 cytidine kinase
2.7.1.48 uridine/cytidine kinase
2.7.1.B20
–
–
–
thiamine_phosphate + ATP <=> thiamine_diphosphate + ADP 2.7.1.21 thymidine kinase
2.7.4.12 T2-induced deoxynucleotide kinase
2.7.4.13 (deoxy)nucleoside-phosphate kinase
2.7.4.16 thiamine-phosphate kinase
2.7.4.3 adenylate kinase
2.7.4.4 nucleoside-phosphate kinase
2.7.4.8 guanylate kinase
2.7.4.9 dTMP kinase
–
–
–
–
–
–
–
–
UDP + H2O <=> phosphate + UMP + H+ 3.1.3.2 acid phosphatase
3.1.3.31 nucleotidase
3.6.1.15 nucleoside-triphosphate phosphatase
3.6.1.22 NAD+ diphosphatase
3.6.1.42 guanosine-diphosphatase
3.6.1.5 apyrase
3.6.1.6 nucleoside diphosphate phosphatase
3.6.1.9 nucleotide diphosphatase
–
–
–
–
–
–
–
–
(Z)-3-ureidoacrylate_peracid + H2O <=> (Z)-3-peroxyaminoacrylate + Carbamate 3.5.1.110 ureidoacrylate amidohydrolase
–
H2O + dTMP <=> phosphate + thymidine 3.1.3.1 alkaline phosphatase
3.1.3.2 acid phosphatase
3.1.3.31 nucleotidase
3.1.3.32 polynucleotide 3'-phosphatase
3.1.3.34 deoxynucleotide 3'-phosphatase
3.1.3.35 thymidylate 5'-phosphatase
3.1.3.5 5'-nucleotidase
3.1.3.89 5'-deoxynucleotidase
–
–
–
–
–
–
–
–
cytosine + H2O + H+ <=> Uracil + NH3 3.5.4.1 cytosine deaminase
3.5.4.3 guanine deaminase
–
–
dTTP + cytidine <=> dTDP + CMP 2.7.1.48 uridine/cytidine kinase
–
5-Methylbarbiturate + H2O <=> 3-Oxo-3-ureidoisobutyrate 3.5.2.1 barbiturase
–
ITP + uridine <=> IDP + UMP 2.7.1.48 uridine/cytidine kinase
–
H+ + Barbiturate + H2O <=> 1-carboxymalonamide 3.5.2.1 barbiturase
–
UDP + ATP <=> UTP + ADP 2.7.4.6 nucleoside-diphosphate kinase
–
cytidine + H2O <=> D-ribose + cytosine 3.2.2.1 purine nucleosidase
3.2.2.3 uridine nucleosidase
3.2.2.7 adenosine nucleosidase
3.2.2.8 ribosylpyrimidine nucleosidase
–
–
–
–
cytidine_2,3''-cyclic_monophosphate + H2O <=> cytidine-3''-monophosphate + H+ 3.1.4.16 2',3'-cyclic-nucleotide 2'-phosphodiesterase
3.1.4.55 phosphoribosyl 1,2-cyclic phosphate phosphodiesterase
4.6.1.18 pancreatic ribonuclease
–
–
–
1-carboxymalonamide + H2O <=> H+ + malonate + Urea 3.5.1.95 N-malonylurea hydrolase
–
uridine + ATP <=> H+ + UMP + ADP 2.4.2.9 uracil phosphoribosyltransferase
2.7.1.145 deoxynucleoside kinase
2.7.1.21 thymidine kinase
2.7.1.213 cytidine kinase
2.7.1.48 uridine/cytidine kinase
2.7.1.B20
–
–
–
–
–
–
N-carbamoyl-beta-aminoisobutyric_acid + H2O + H+ <=> (R)-3-Amino-2-methylpropanoate + NH3 + CO2 3.5.1.6 beta-ureidopropionase
–
dUMP + H2O <=> 2''-deoxyuridine + phosphate 3.1.3.2 acid phosphatase
3.1.3.31 nucleotidase
3.1.3.34 deoxynucleotide 3'-phosphatase
3.1.3.35 thymidylate 5'-phosphatase
3.1.3.5 5'-nucleotidase
3.1.3.89 5'-deoxynucleotidase
–
–
–
–
–
–
dGTP + uridine <=> dGDP + UMP 2.7.1.48 uridine/cytidine kinase
–
dUDP + thioredoxin_disulfide + H2O <=> UDP + thioredoxin 1.17.4.1 ribonucleoside-diphosphate reductase
1.17.4.2 ribonucleoside-triphosphate reductase (thioredoxin)
–
–
(Z)-3-ureidoacrylate_peracid + NADH <=> ureidoacrylate + NAD+ + H2O not assigned
 –
thymidine + ATP <=> H+ + dTMP + ADP 2.7.1.145 deoxynucleoside kinase
2.7.1.21 thymidine kinase
2.7.1.74 deoxycytidine kinase
2.7.1.76 2'-deoxyadenosine kinase
2.7.1.77 nucleoside phosphotransferase
2.7.4.9 dTMP kinase
–
–
–
–
–
–
H2O + 5,6-dihydrouracil <=> H+ + N-Carbamoyl-beta-alanine 3.5.2.16 maleimide hydrolase
3.5.2.2 dihydropyrimidinase
–
–
ureidoacrylate + H2O <=> 2-aminoacrylate + Carbamate + H+ 3.5.1.110 ureidoacrylate amidohydrolase
–
thymine + H2O + acceptor <=> 5-Methylbarbiturate + reduced_acceptor + H+ 1.17.99.4 uracil/thymine dehydrogenase
–
H2O + UTP <=> H+ + phosphate + UDP 3.1.3.2 acid phosphatase
3.1.3.31 nucleotidase
3.1.3.5 5'-nucleotidase
3.1.3.8 3-phytase
3.6.1.15 nucleoside-triphosphate phosphatase
3.6.1.28 thiamine-triphosphatase
3.6.1.39 thymidine-triphosphatase
3.6.1.45 UDP-sugar diphosphatase
3.6.1.5 apyrase
3.6.1.6 nucleoside diphosphate phosphatase
3.6.1.9 nucleotide diphosphatase
3.6.1.B17
3.6.4.12 DNA helicase
3.6.4.13 RNA helicase
3.6.4.B10
3.6.4.B6
7.1.2.1 P-type H+-exporting transporter
7.1.2.2 H+-transporting two-sector ATPase
7.6.2.2 ABC-type xenobiotic transporter
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
dGTP + cytidine <=> dGDP + CMP 2.7.1.48 uridine/cytidine kinase
–
dUTP + uridine <=> dUDP + UMP 2.7.1.48 uridine/cytidine kinase
–
H+ + dCMP + H2O <=> NH3 + dUMP 3.5.4.12 dCMP deaminase
–
dTTP + H2O <=> dTMP + diphosphate + H+ 3.6.1.12 dCTP diphosphatase
3.6.1.23 dUTP diphosphatase
3.6.1.39 thymidine-triphosphatase
3.6.1.55 8-oxo-dGTP diphosphatase
3.6.1.65 (d)CTP diphosphatase
3.6.1.8 ATP diphosphatase
3.6.1.9 nucleotide diphosphatase
–
–
–
–
–
–
–
L-dihydroorotate + H2O <=> H+ + L-carbamoyl-L-aspartate 3.5.2.3 dihydroorotase
–
2''-Deoxy-5-hydroxymethylcytidine-5''-diphosphate + ATP <=> 2''-Deoxy-5-hydroxymethylcytidine-5''-triphosphate + ADP 2.7.4.6 nucleoside-diphosphate kinase
–
(R)-5,6-Dihydrothymine + NADP+ <=> thymine + NADPH + H+ 1.3.1.2 dihydropyrimidine dehydrogenase (NADP+)
–
H+ + CTP + H2O <=> UTP + NH3 3.5.4.13 dCTP deaminase
3.5.4.5 cytidine deaminase
–
–
(Z)-3-peroxyaminoacrylate <=> 2-aminoacrylate not assigned
 –
H+ + orotidine_5''-phosphate <=> CO2 + UMP 4.1.1.23 orotidine-5'-phosphate decarboxylase
–
2''-deoxyuridine + ATP <=> H+ + dUMP + ADP 2.7.1.145 deoxynucleoside kinase
2.7.1.21 thymidine kinase
2.7.1.74 deoxycytidine kinase
2.7.1.76 2'-deoxyadenosine kinase
–
–
–
–
ATP + dUMP <=> ADP + dUDP 2.7.4.13 (deoxy)nucleoside-phosphate kinase
2.7.4.14 UMP/CMP kinase
2.7.4.22 UMP kinase
2.7.4.25 (d)CMP kinase
2.7.4.4 nucleoside-phosphate kinase
2.7.4.9 dTMP kinase
2.7.4.B1
–
–
–
–
–
–
–
ATP + 5-hydroxymethyl-dCMP <=> ADP + 5-hydroxymethyl-dCDP 2.7.4.12 T2-induced deoxynucleotide kinase
–

Visualization of the pathway